"Small Town Prescription" tells the story of a talented doctor named Liu Zhengliang (played by Xiao Zhan), who encounters a setback in life and is forced to return to his hometown to start from scratch. He gathers a group of "unreliable" people and passionately tackles the "most reliable" tasks. He weaves the warmth of human nature into the daily life of the city, prescribing life prescriptions that heal the soul.